HEY1 抗体
Quick Overview for HEY1 抗体 (ABIN7114852)
抗原
See all HEY1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- HEY1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- hairy/enhancer-of-split related with YRPW motif 1
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亚型
- IgG
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应用备注
- WB: 1:500-1:5000, IP: 1:200-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- HEY1 (Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1))
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别名
- HEY1
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背景
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Synonyms: Hairy/enhancer-of-split related with YRPW motif protein 1|Cardiovascular helix-loop-helix factor 2 (CHF-2)|Class B basic helix-loop-helix protein 31 (bHLHb31)|HES-related repressor protein 1|Hairy and enhancer of split-related protein 1 (HESR-1)|Hairy-related transcription factor 1 (HRT-1, hHRT1)|HEY1|BHLHB31|CHF2|HERP2|HESR1|HRT1
Background: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'(PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3(PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal(PubMed:25985737).
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分子量
- 33 kDa
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基因ID
- 23462
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UniProt
- Q9Y5J3
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途径
- Tube Formation
抗原
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